1374239-71-0
1374239-71-0 structure
- Name: BTK-IN-18
- Chemical Name: BTK-IN-18
- CAS Number: 1374239-71-0
- Molecular Formula: C20H22Cl2N6O
- Molecular Weight: 433.33
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Btk
- Create Date: 2023-04-04 09:44:06
- Modify Date: 2024-04-03 08:33:26
-
BTK-IN-18 is a potent, reversible BTK inhibitor with an IC50 of 0.002 µM. BTK-IN-18 inhibits both CD69 and CD86 in vivo[1].
| Name | BTK-IN-18 |
|---|
| Description | BTK-IN-18 is a potent, reversible BTK inhibitor with an IC50 of 0.002 µM. BTK-IN-18 inhibits both CD69 and CD86 in vivo[1]. |
|---|---|
| Related Catalog | |
| In Vivo | BTK-IN-18 (化合物 41; 10, 25, 45 mg/kg; 腹腔给药; 单剂量) 对 CD69 和 CD86 产生强烈的剂量依赖性抑制[1]。 BTK-IN-18 (静脉给药; 1 mg/kg) 在大鼠中的 T1/2 为 5.3 小时，CL 为 19 mL/min/kg，Vss 为 1.3 L/kg[1]。 Animal Model: Mice[1] Dosage: 10, 25, 45 mg/kg Administration: IP; single dose Result: Caused robust dose-dependent inhibition of both CD69 and CD86 (74.8 %, 50.3 %, and 21.5 % respectively). Animal Model: Dosage: Administration: Result: Pharmacokinetic Parameters of BTK-IN-18 in rats[1]. IV (1 mg/kg) PO (5 mg/kg) Tmax (h) 1.6 Cmax (h∗mg/mL) 321 AUCinfi (h∗mg/mL) 1013 1421 t1/2 (ng/mL) 5.3 CL (mL/min/kg) 19 Vss (L/kg) 1.3 F (%) 23% |
| References |
| Molecular Formula | C20H22Cl2N6O |
|---|---|
| Molecular Weight | 433.33 |