BTK-IN-22

Names

[ CAS No. ]:
2573048-10-7

[ Name ]:
BTK-IN-22

Biological Activity

[Description]:

BTK-IN-22 is a BTK inhibitor (IC50: 0.9 nM). BTK-IN-22 also inhibits BLX and BMX with IC50s of 1.4 and 1.2 nM respectively. BTK-IN-22 shows improved kinase selectivity compared to Ibrutinib (HY-10997)[1]

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk

[In Vitro]

BTK-IN-23 (Compound 2) 抑制 Jeko-1 细胞中 BTK 自磷酸化，IC50 值为 109 nM[1]. Western Blot Analysis[1] Cell Line: Jeko-1 cell Concentration: 0.01, 0.1, 1, 10 μM Incubation Time: 2 h Result: Inhibited BTK autophosphorylation.

[References]

[1]. Sean T. Toenjes, et al. Controlling Ibrutinib’s Conformations about Its Heterobiaryl Axis to Increase BTK Selectivity. ACS Med. Chem. Lett. 2023. https://doi.org/10.1021/acsmedchemlett.2c00523

Chemical & Physical Properties

[ Molecular Formula ]:
C26H26N6O2

[ Molecular Weight ]:
454.52

Related Compounds