BTK-IN-23
Modify Date: 2025-08-25 19:06:42
BTK-IN-23 structure
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Common Name | BTK-IN-23 | ||
|---|---|---|---|---|
| CAS Number | 1227206-13-4 | Molecular Weight | 529.594 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H24FN7O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BTK-IN-23BTK-IN-23 is a highly potent and selective Btk inhibitor with IC50 of 3 nM; displays 5-fold and 77-fold selectivity over BMX and TEC, >300-fold selectivity over FGR, SRC and MELK; demonstrates potent inhibition of anti-IgE stimulated CD63 expression on basophils, with an EC50 of 257 nM; shows improved stability compared to GDC-0834. |
| Name | BTK-IN-23 |
|---|
| Description | BTK-IN-23 is a highly potent and selective Btk inhibitor with IC50 of 3 nM; displays 5-fold and 77-fold selectivity over BMX and TEC, >300-fold selectivity over FGR, SRC and MELK; demonstrates potent inhibition of anti-IgE stimulated CD63 expression on basophils, with an EC50 of 257 nM; shows improved stability compared to GDC-0834. |
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| References | References 1. Young WB, et al. Bioorg Med Chem Lett. 2016 Jan 15;26(2):575-9. View Related Products by Target BTK |
| Molecular Formula | C27H24FN7O2S |
|---|---|
| Molecular Weight | 529.594 |
| InChIKey | MZSDTUIZKGUVHK-UHFFFAOYSA-N |
| SMILES | Cc1c(-c2cc(Nc3cc4n(n3)CCN(C)C4)c(=O)[nH]n2)ccc(F)c1NC(=O)c1cc2ccccc2s1 |