TbPTR1 inhibitor 1

Modify Date: 2024-04-05 18:51:04

TbPTR1 inhibitor 1 Structure
TbPTR1 inhibitor 1 structure
Common Name TbPTR1 inhibitor 1
CAS Number 2499713-65-2 Molecular Weight 399.45
Density N/A Boiling Point N/A
Molecular Formula C22H21N7O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TbPTR1 inhibitor 1


TbPTR1 inhibitor 1 (compound 5d) is a potent kinetoplastid pteridine reductase 1 (PTR1) inhibitor with an IC50<0.1 nM for TbPTR1. TbPTR1 inhibitor 1 has inhibitory activity against Trypanosoma brucei (EC50=0.66 μM)[1].

 Names

Name TbPTR1 inhibitor 1

 TbPTR1 inhibitor 1 Biological Activity

Description TbPTR1 inhibitor 1 (compound 5d) is a potent kinetoplastid pteridine reductase 1 (PTR1) inhibitor with an IC50<0.1 nM for TbPTR1. TbPTR1 inhibitor 1 has inhibitory activity against Trypanosoma brucei (EC50=0.66 μM)[1].
Related Catalog
Target

IC50: <0.1 nM (TbPTR1)[1]

References

[1]. Pöhner I, et al. Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1. J Med Chem. 2022 Jun 8.

 Chemical & Physical Properties

Molecular Formula C22H21N7O
Molecular Weight 399.45
InChIKey ASBJYAZYFSRQAB-UHFFFAOYSA-N
SMILES CCN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)c2ccccc2)cc1
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