TbPTR1 inhibitor 1

Names

[ Name ]:
TbPTR1 inhibitor 1

Biological Activity

[Description]:

TbPTR1 inhibitor 1 (compound 5d) is a potent kinetoplastid pteridine reductase 1 (PTR1) inhibitor with an IC50<0.1 nM for TbPTR1. TbPTR1 inhibitor 1 has inhibitory activity against Trypanosoma brucei (EC50=0.66 μM)[1].

[Related Catalog]:

Research Areas >> Infection

[Target]

IC50: <0.1 nM (TbPTR1)[1]

[References]

[1]. Pöhner I, et al. Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1. J Med Chem. 2022 Jun 8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₁N₇O

[ Molecular Weight ]:
399.45

Related Compounds

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