855998-46-8

855998-46-8 structure

855998-46-8 structure

Name: Thrombin inhibitor 1
Chemical Name: Thrombin inhibitor 1
CAS Number: 855998-46-8
Molecular Formula: C₂₂H₂₀Cl₂F₂N₄O₃
Molecular Weight: 497.32
Catalog: Signaling Pathways Metabolic Enzyme/Protease Thrombin
Create Date: 2018-01-08 12:57:48
Modify Date: 2024-01-20 01:05:30
Thrombin inhibitor 1 is a potent thrombin inhibitor (Ki=0.66 nM, 2xaPTT=0.43 μM).

Name	Thrombin inhibitor 1

Description	Thrombin inhibitor 1 is a potent thrombin inhibitor (Ki=0.66 nM, 2xaPTT=0.43 μM).
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Thrombin Research Areas >> Cardiovascular Disease
Target	Ki: 0.66 nM (thrombin)[1]
In Vitro	Thrombin inhibitor 1 (Compound 4) is binds in the active site of thrombin with Ki of 0.66 nM, 2xaPTT=0.43 uM). Thrombin inhibitor 1 (Compound 4) is evaluated for its thrombin inhibitory potency and its functional ability to double the activated partial thromboplastin time (2xaPTT) in human plasma with a 2xaPTT of 0.43 μM[1].
References	[1]. Nantermet PG, et al. P2 pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2771-5.

Molecular Formula	C₂₂H₂₀Cl₂F₂N₄O₃
Molecular Weight	497.32