SARS-CoV-IN-4
Modify Date: 2025-08-26 18:10:26
SARS-CoV-IN-4 structure
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Common Name | SARS-CoV-IN-4 | ||
|---|---|---|---|---|
| CAS Number | 2445585-37-3 | Molecular Weight | 779.14 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H31ClN12O11S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SARS-CoV-IN-4SARS-CoV-IN-4 (compound 13) is a potent and specific inhibitor of SARS-CoV nsp14 N7-methyltransferase, with an IC50 of 0.6 μM (SARS-CoV nsp14)[1]. |
| Name | SARS-CoV-IN-4 |
|---|
| Description | SARS-CoV-IN-4 (compound 13) is a potent and specific inhibitor of SARS-CoV nsp14 N7-methyltransferase, with an IC50 of 0.6 μM (SARS-CoV nsp14)[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.6 ± 0.1 μM (SARS-CoV nsp14), 247.5 ± 14.9 μM (hRNMT)[1] |
| In Vitro | SARS-CoV-IN-4 (compound 13) shows inhibitory activity on N7-MTases, with inhibition at 50 μM of 97.2 ± 2.7% (SARS-CoV nsp14), and 33.9 ± 3.3% (hRNMT), respectively[1]. SARS-CoV-IN-4 stabilizes SARS-CoV nsp14 against thermal denaturation with a ΔTm +10.8 °C and exhibits notable binding affinity (apparent KD 1.3 ± 0.87 μM)[1]. |
| References |
| Molecular Formula | C28H31ClN12O11S |
|---|---|
| Molecular Weight | 779.14 |
| InChIKey | STBVZHYGQWMMTR-DWVGVLABSA-N |
| SMILES | Nc1ncnc2c1ncn2C1OC(CN(CCOC2C(O)C(CO)OC2n2cnc3c(N)ncnc32)S(=O)(=O)c2ccc(Cl)c([N+](=O)[O-])c2)C(O)C1O |