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2445585-37-3

2445585-37-3 structure

2445585-37-3 structure

Name: SARS-CoV-IN-4
Chemical Name: SARS-CoV-IN-4
CAS Number: 2445585-37-3
Molecular Formula: C₂₈H₃₁ClN₁₂O₁₁S
Molecular Weight: 779.14
Catalog: Signaling Pathways Anti-infection SARS-CoV
Create Date: 2022-07-01 17:02:18
Modify Date: 2025-08-26 18:10:26
SARS-CoV-IN-4 (compound 13) is a potent and specific inhibitor of SARS-CoV nsp14 N7-methyltransferase, with an IC50 of 0.6 μM (SARS-CoV nsp14)[1].

Name	SARS-CoV-IN-4

Description	SARS-CoV-IN-4 (compound 13) is a potent and specific inhibitor of SARS-CoV nsp14 N7-methyltransferase, with an IC50 of 0.6 μM (SARS-CoV nsp14)[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
Target	IC50: 0.6 ± 0.1 μM (SARS-CoV nsp14), 247.5 ± 14.9 μM (hRNMT)[1]
In Vitro	SARS-CoV-IN-4 (compound 13) shows inhibitory activity on N7-MTases, with inhibition at 50 μM of 97.2 ± 2.7% (SARS-CoV nsp14), and 33.9 ± 3.3% (hRNMT), respectively[1]. SARS-CoV-IN-4 stabilizes SARS-CoV nsp14 against thermal denaturation with a ΔTm +10.8 °C and exhibits notable binding affinity (apparent KD 1.3 ± 0.87 μM)[1].
References	[1]. Ahmed-Belkacem R, et al. Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase. Eur J Med Chem. 2020 Sep 1;201:112557.

Molecular Formula	C₂₈H₃₁ClN₁₂O₁₁S
Molecular Weight	779.14

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