888958-27-8

888958-27-8 structure

Name: SARS-CoV-IN-3
Chemical Name: SARS-CoV-IN-3
CAS Number: 888958-27-8
Molecular Formula: C₂₅H₂₀ClFeN₃O
Molecular Weight: 469.74
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2020-04-10 12:12:08
Modify Date: 2024-01-09 16:13:09
SARS-CoV-IN-3 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-3 shows anti-Coronavirus activity with an EC50 of 3.6 μM in Vero cells. SARS-CoV-IN-3 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 11.7 and 20.4 nM; and IC90s of 29.19 and 56 nM; respectively. SARS-CoV-IN-3 reduces HIV-1-induced cytopathic effect with an EC50 of 10 μM in MT-4 cells[1].

Name	SARS-CoV-IN-3

Description	SARS-CoV-IN-3 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-3 shows anti-Coronavirus activity with an EC50 of 3.6 μM in Vero cells. SARS-CoV-IN-3 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 11.7 and 20.4 nM; and IC90s of 29.19 and 56 nM; respectively. SARS-CoV-IN-3 reduces HIV-1-induced cytopathic effect with an EC50 of 10 μM in MT-4 cells[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
Target	EC50: 3.6 μM (SARS-CoV, in Vero cells)[1] IC50: 11.7 nM (3D7 P. falciparum), 20.4 nM (W2 P. falciparum)[1] IC90: 29.19 nM (3D7 P. falciparum), 56 nM (W2 P. falciparum)[1]
In Vitro	SARS-CoV-IN-3 (Compound 4) inhibits in vitro growth of Plasmodium falciparum far better than Chloroquine (CQ) [1].
References	[1]. Biot C, et al. Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities. J Med Chem. 2006 May 4;49(9):2845-9.

Molecular Formula	C₂₅H₂₀ClFeN₃O
Molecular Weight	469.74