SARS-CoV-IN-2

Modify Date: 2024-01-09 23:05:14

SARS-CoV-IN-2 structure	Common Name	SARS-CoV-IN-2
	CAS Number	888958-26-7	Molecular Weight	455.72
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₁₈ClFeN₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SARS-CoV-IN-2

SARS-CoV-IN-2 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-2 shows anti-Coronavirus activity with an EC50 of 1.9 μM in Vero cells. SARS-CoV-IN-2 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 21.5 and 30 nM; and IC90s of 51.0 and 99.9 nM; respectively. SARS-CoV-IN-2 reduces HIV-1-induced cytopathic effect with an EC50 of 2.9 μM in MT-4 cells. Antimalarial and Antiviral Activities[1].

Name	SARS-CoV-IN-2

Description	SARS-CoV-IN-2 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-2 shows anti-Coronavirus activity with an EC50 of 1.9 μM in Vero cells. SARS-CoV-IN-2 inhibits the 3D7 and W2 strains of P. falciparum with IC50s of 21.5 and 30 nM; and IC90s of 51.0 and 99.9 nM; respectively. SARS-CoV-IN-2 reduces HIV-1-induced cytopathic effect with an EC50 of 2.9 μM in MT-4 cells. Antimalarial and Antiviral Activities[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
Target	EC50: 1.9 μM (SARS-CoV, in Vero cells)[1] IC50: 21.5 nM (3D7 P. falciparum), 30 nM (W2 P. falciparum)[1] IC90: 51.0 nM (3D7 P. falciparum), 99.9 nM (W2 P. falciparum)[1]
In Vitro	SARS-CoV-IN-2 (Compound 3) inhibits in vitro growth of Plasmodium falciparum far better than Chloroquine (CQ) [1].
References	[1]. Biot C, et al. Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities. J Med Chem. 2006 May 4;49(9):2845-9.

Molecular Formula	C₂₄H₁₈ClFeN₃O
Molecular Weight	455.72

SARS-CoV-IN-2

Use of SARS-CoV-IN-2

Names

SARS-CoV-IN-2 Biological Activity

Chemical & Physical Properties