MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan

Modify Date: 2025-11-07 17:00:14

MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan structure	Common Name	MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan
	CAS Number	2414254-52-5	Molecular Weight	1074.12
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅₅H₆₀FN₉O₁₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan

MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan is a drug-linker conjugates for ADC, consisting Exatecan (HY-13631). Exatecan is a DNA Topoisomerase I inhibitor (IC50=2.2 μM)[1].

Name	MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan

Description	MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan is a drug-linker conjugates for ADC, consisting Exatecan (HY-13631). Exatecan is a DNA Topoisomerase I inhibitor (IC50=2.2 μM)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	Topoisomerase I
References	[1]. Ying Hua, et al. Anti-B7H3 antibody-exatecan analog conjugate and medicinal use thereof: World Intellectual Property Organization, WO2020063673. 2020-04-02.

Molecular Formula	C₅₅H₆₀FN₉O₁₃
Molecular Weight	1074.12
InChIKey	WKCCHLIWLNJSMH-KMJSUKHOSA-N
SMILES	CCC1(O)C(=O)OCc2c1cc1n(c2=O)Cc2c-1nc1cc(F)c(C)c3c1c2C(NC(=O)C(OCNC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)CCCCCN1C(=O)C=CC1=O)C1CC1)CC3

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