MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan

Names

[ CAS No. ]:
2414254-52-5

[ Name ]:
MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan

Biological Activity

[Description]:

MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan is a drug-linker conjugates for ADC, consisting Exatecan (HY-13631). Exatecan is a DNA Topoisomerase I inhibitor (IC50=2.2 μM)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

[Target]

Topoisomerase I


[References]

[1]. Ying Hua, et al. Anti-B7H3 antibody-exatecan analog conjugate and medicinal use thereof: World Intellectual Property Organization, WO2020063673. 2020-04-02.

Chemical & Physical Properties

[ Molecular Formula ]:
C55H60FN9O13

[ Molecular Weight ]:
1074.12

Related Compounds