CYP4A11/CYP4F2-IN-2

Modify Date: 2024-02-20 21:24:13

CYP4A11/CYP4F2-IN-2 Structure
CYP4A11/CYP4F2-IN-2 structure
Common Name CYP4A11/CYP4F2-IN-2
CAS Number 2280834-99-1 Molecular Weight 361.44
Density N/A Boiling Point N/A
Molecular Formula C19H27N3O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CYP4A11/CYP4F2-IN-2


CYP4A11/CYP4F2-IN-2 (compound 15) is an orally available inhibitor of CYP4A11/4F2 with IC50s of 120 nM and 220 nM, respectively. CYP4A11/CYP4F2-IN-2 inhibits 20-HETE production in rat kidney and has potential inhibitory effects on diabetic nephropathy and autosomal dominant polycystic kidney disease[1].

 Names

Name CYP4A11/CYP4F2-IN-2

 CYP4A11/CYP4F2-IN-2 Biological Activity

Description CYP4A11/CYP4F2-IN-2 (compound 15) is an orally available inhibitor of CYP4A11/4F2 with IC50s of 120 nM and 220 nM, respectively. CYP4A11/CYP4F2-IN-2 inhibits 20-HETE production in rat kidney and has potential inhibitory effects on diabetic nephropathy and autosomal dominant polycystic kidney disease[1].
Related Catalog
Target

CYP4A11, CYP4F2[1]

References

[1]. Kawamura M et al. Introduction of a carboxylic acid group into pyrazolylpyridine derivatives increased selectivity for inhibition of the 20-HETE synthase CYP4A11/4F2[J]. Bioorganic & Medicinal Chemistry, 2023: 117505.

 Chemical & Physical Properties

Molecular Formula C19H27N3O4
Molecular Weight 361.44
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