937727-03-2
937727-03-2 structure
- Name: HDAC1,2-IN-2
- Chemical Name: HDAC1,2-IN-2
- CAS Number: 937727-03-2
- Molecular Formula: C23H23N5O3S
- Molecular Weight: 449.529
- Create Date: 2020-01-11 12:52:41
- Modify Date: 2024-04-01 11:42:03
-
A potent, selective HDAC1 and HDAC2 inhibitor with IC50 of 6 nM and 45 nM, respectively; displays highly selectivity over HDAC3 (IC50=7.0 μM), HDAC8 and 11 (IC50=20-25 uM) and no activity on HDACs 4-7; increases lysine 5 of histone H2B (H2BK5) in HCT116 colon carcinoma cells with IC50 of 400 nM, inhibited the cell growth with GI50 of 97 nM; exhibits tumor growth inhibition in HCT116 xenograft mice.
| Name | HDAC1,2-IN-2 |
|---|
| Description | A potent, selective HDAC1 and HDAC2 inhibitor with IC50 of 6 nM and 45 nM, respectively; displays highly selectivity over HDAC3 (IC50=7.0 μM), HDAC8 and 11 (IC50=20-25 uM) and no activity on HDACs 4-7; increases lysine 5 of histone H2B (H2BK5) in HCT116 colon carcinoma cells with IC50 of 400 nM, inhibited the cell growth with GI50 of 97 nM; exhibits tumor growth inhibition in HCT116 xenograft mice. |
|---|---|
| References | References 1. Hamblett CL, et al. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5300-9. 2. Methot JL, et al. ACS Med Chem Lett. 2014 Jan 2;5(4):340-5. View Related Products by Target HDAC |
| Molecular Formula | C23H23N5O3S |
|---|---|
| Molecular Weight | 449.529 |