Mutated EGFR-IN-2
Modify Date: 2025-08-25 19:23:28
Mutated EGFR-IN-2 structure
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Common Name | Mutated EGFR-IN-2 | ||
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| CAS Number | 2050906-97-1 | Molecular Weight | 562.64 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H35FN8O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Mutated EGFR-IN-2Mutated EGFR-IN-2 (compound 91) is a mutant-selective EGFR inhibitor extracted from patent WO2017036263A1, which potently inhibits single-mutant EGFR (T790M) and double-mutant EGFR (including L858R/T790M (IC50=＜1nM) and ex19del/T790M), and can suppress activity of single gain-of-function mutant EGFR (including L858R and ex19del) as well. Mutated EGFR-IN-2 shows anti-tumor antivity[1]. |
| Name | Mutated EGFR-IN-2 |
|---|
| Description | Mutated EGFR-IN-2 (compound 91) is a mutant-selective EGFR inhibitor extracted from patent WO2017036263A1, which potently inhibits single-mutant EGFR (T790M) and double-mutant EGFR (including L858R/T790M (IC50=＜1nM) and ex19del/T790M), and can suppress activity of single gain-of-function mutant EGFR (including L858R and ex19del) as well. Mutated EGFR-IN-2 shows anti-tumor antivity[1]. |
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| Related Catalog | |
| Target |
EGFRT790M EGFRL858R EGFRex19del EGFR (L858R/T790M):<1 nM (IC50) EGFR (ex19del/T790M) |
| References |
| Molecular Formula | C29H35FN8O3 |
|---|---|
| Molecular Weight | 562.64 |