Mutated EGFR-IN-2
Names
[ CAS No. ]:
2050906-97-1
[ Name ]:
Mutated EGFR-IN-2
Biological Activity
[Description]:
Mutated EGFR-IN-2 (compound 91) is a mutant-selective EGFR inhibitor extracted from patent WO2017036263A1, which potently inhibits single-mutant EGFR (T790M) and double-mutant EGFR (including L858R/T790M (IC50=<1nM) and ex19del/T790M), and can suppress activity of single gain-of-function mutant EGFR (including L858R and ex19del) as well. Mutated EGFR-IN-2 shows anti-tumor antivity[1].
[Related Catalog]:
[Target]
EGFRT790M
EGFRL858R
EGFRex19del
EGFR (L858R/T790M):<1 nM (IC50)
EGFR (ex19del/T790M)
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C29H35FN8O3
[ Molecular Weight ]:
562.64