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Mutated EGFR-IN-1

Names

[ CAS No. ]:
1421372-66-8

[ Name ]:
Mutated EGFR-IN-1

[Synonym ]:
Mutated EGFR-IN-1
AZD9291 intermediate 3
1,2,4-Benzenetriamine, N-[2-(dimethylamino)ethyl]-5-methoxy-N-methyl-N-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-
N-[2-(Dimethylamino)ethyl]-5-methoxy-N-methyl-N-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-1,2,4-benzenetriamine
N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N 1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]benzene-1,2,4-triamine

Biological Activity

[Description]:

Mutated EGFR-IN-1 is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant.IC50 value:Target: Mutated EGFR inhibitorMore information can be found in Patent WO 2013014448 A1.2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer.

[Related Catalog]:

Research Areas >> Cancer

[Target]

EGFRL858R

EGFRExon 19 deletion/T790M

EGFRT790M


[References]

[1]. Patent WO 2013014448 A1. 2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer.


[Related Small Molecules]

Osimertinib (AZD9291) | Tyrphostin B42 (AG-490) | Neratinib (HKI-272) | Genistein | (-)-Epigallocatechin gallate | AG-1478 | Dacomitinib (PF-00299804) | Irbinitinib | Poziotinib | Olmutinib | Sapitinib | AZD-3759 | Pyrotinib | Canertinib dihydrochloride | BMS-690514

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
676.5±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H31N7O

[ Molecular Weight ]:
445.560

[ Flash Point ]:
363.0±34.3 °C

[ Exact Mass ]:
445.259003

[ PSA ]:
84.47000

[ LogP ]:
2.17

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.635

[ Storage condition ]:
2-8℃

Related Compounds

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