Mutated EGFR-IN-2

Modify Date: 2024-01-12 13:12:55

Mutated EGFR-IN-2 Structure
Mutated EGFR-IN-2 structure
Common Name Mutated EGFR-IN-2
CAS Number 2050906-97-1 Molecular Weight 562.64
Density N/A Boiling Point N/A
Molecular Formula C29H35FN8O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Mutated EGFR-IN-2


Mutated EGFR-IN-2 (compound 91) is a mutant-selective EGFR inhibitor extracted from patent WO2017036263A1, which potently inhibits single-mutant EGFR (T790M) and double-mutant EGFR (including L858R/T790M (IC50=<1nM) and ex19del/T790M), and can suppress activity of single gain-of-function mutant EGFR (including L858R and ex19del) as well. Mutated EGFR-IN-2 shows anti-tumor antivity[1].

 Names

Name Mutated EGFR-IN-2

 Mutated EGFR-IN-2 Biological Activity

Description Mutated EGFR-IN-2 (compound 91) is a mutant-selective EGFR inhibitor extracted from patent WO2017036263A1, which potently inhibits single-mutant EGFR (T790M) and double-mutant EGFR (including L858R/T790M (IC50=<1nM) and ex19del/T790M), and can suppress activity of single gain-of-function mutant EGFR (including L858R and ex19del) as well. Mutated EGFR-IN-2 shows anti-tumor antivity[1].
Related Catalog
Target

EGFRT790M

EGFRL858R

EGFRex19del

EGFR (L858R/T790M):<1 nM (IC50)

EGFR (ex19del/T790M)

References

[1]. 2, 4-di-(nitrogen containing group) substituted pyrimidine compound and preparation method and use thereof.

 Chemical & Physical Properties

Molecular Formula C29H35FN8O3
Molecular Weight 562.64