Mutated EGFR-IN-1
Modify Date: 2025-08-25 13:53:07
Mutated EGFR-IN-1 structure
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Common Name | Mutated EGFR-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 1421372-66-8 | Molecular Weight | 445.560 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 676.5±65.0 °C at 760 mmHg | |
| Molecular Formula | C25H31N7O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 363.0±34.3 °C | |
Use of Mutated EGFR-IN-1Mutated EGFR-IN-1 is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant.IC50 value:Target: Mutated EGFR inhibitorMore information can be found in Patent WO 2013014448 A1.2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer. |
| Name | N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine |
|---|---|
| Synonym | More Synonyms |
| Description | Mutated EGFR-IN-1 is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant.IC50 value:Target: Mutated EGFR inhibitorMore information can be found in Patent WO 2013014448 A1.2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer. |
|---|---|
| Related Catalog | |
| Target |
EGFRL858R EGFRExon 19 deletion/T790M EGFRT790M |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 676.5±65.0 °C at 760 mmHg |
| Molecular Formula | C25H31N7O |
| Molecular Weight | 445.560 |
| Flash Point | 363.0±34.3 °C |
| Exact Mass | 445.259003 |
| PSA | 84.47000 |
| LogP | 2.17 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.635 |
| Storage condition | 2-8℃ |
| Mutated EGFR-IN-1 |
| AZD9291 intermediate 3 |
| 1,2,4-Benzenetriamine, N-[2-(dimethylamino)ethyl]-5-methoxy-N-methyl-N-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]- |
| N-[2-(Dimethylamino)ethyl]-5-methoxy-N-methyl-N-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-1,2,4-benzenetriamine |
| N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N 1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]benzene-1,2,4-triamine |
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- China
- Product Name: N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine
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- Purity: 99.0%
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