2492429-45-3

2492429-45-3 structure

Name: EGFR/BRAFV600E-IN-1
Chemical Name: EGFR/BRAFV600E-IN-1
CAS Number: 2492429-45-3
Molecular Formula: C₂₄H₂₄ClN₃O₃
Molecular Weight: 437.92
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-08-22 19:07:26
Modify Date: 2024-01-02 19:13:08
EGFR/BRAFV600E-IN-1 (Compound 23) is a potent EGFR and BRAFV600E dual inhibitor with IC50s of 0.08 and 0.15 µM, respectively. EGFR/BRAFV600E-IN-1 induces apoptosis and cell cycle arrest in both pre-G1 and G2/M phases. EGFR/BRAFV600E-IN-1 exhibits antiproliferative activity againist A-549, MCF-7, Panc-1, HT-29 with IC50s of 1.2, 0.79, 1.3, and 1.23 µM, respectively[1].

Name	EGFR/BRAFV600E-IN-1

Description	EGFR/BRAFV600E-IN-1 (Compound 23) is a potent EGFR and BRAFV600E dual inhibitor with IC50s of 0.08 and 0.15 µM, respectively. EGFR/BRAFV600E-IN-1 induces apoptosis and cell cycle arrest in both pre-G1 and G2/M phases. EGFR/BRAFV600E-IN-1 exhibits antiproliferative activity againist A-549, MCF-7, Panc-1, HT-29 with IC50s of 1.2, 0.79, 1.3, and 1.23 µM, respectively[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> MAPK/ERK Pathway >> Raf
References	[1]. Lamya H Al-Wahaibi, et al. Design and synthesis of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as antiproliferative EGFR and BRAF V600E dual inhibitors. Bioorg Chem. 2020 Nov;104:104260.

Molecular Formula	C₂₄H₂₄ClN₃O₃
Molecular Weight	437.92