CYP4A11/CYP4F2-IN-2

Names

[ CAS No. ]:
2280834-99-1

[ Name ]:
CYP4A11/CYP4F2-IN-2

Biological Activity

[Description]:

CYP4A11/CYP4F2-IN-2 (compound 15) is an orally available inhibitor of CYP4A11/4F2 with IC50s of 120 nM and 220 nM, respectively. CYP4A11/CYP4F2-IN-2 inhibits 20-HETE production in rat kidney and has potential inhibitory effects on diabetic nephropathy and autosomal dominant polycystic kidney disease[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Research Areas >> Metabolic Disease

[Target]

CYP4A11, CYP4F2[1]


[References]

[1]. Kawamura M et al. Introduction of a carboxylic acid group into pyrazolylpyridine derivatives increased selectivity for inhibition of the 20-HETE synthase CYP4A11/4F2[J]. Bioorganic & Medicinal Chemistry, 2023: 117505.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H27N3O4

[ Molecular Weight ]:
361.44

Related Compounds

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