2280834-99-1

2280834-99-1 structure

Name: CYP4A11/CYP4F2-IN-2
Chemical Name: CYP4A11/CYP4F2-IN-2
CAS Number: 2280834-99-1
Molecular Formula: C₁₉H₂₇N₃O₄
Molecular Weight: 361.44
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
Create Date: 2024-02-20 21:24:13
Modify Date: 2025-08-26 19:27:56
CYP4A11/CYP4F2-IN-2 (compound 15) is an orally available inhibitor of CYP4A11/4F2 with IC50s of 120 nM and 220 nM, respectively. CYP4A11/CYP4F2-IN-2 inhibits 20-HETE production in rat kidney and has potential inhibitory effects on diabetic nephropathy and autosomal dominant polycystic kidney disease[1].

Name	CYP4A11/CYP4F2-IN-2

Description	CYP4A11/CYP4F2-IN-2 (compound 15) is an orally available inhibitor of CYP4A11/4F2 with IC50s of 120 nM and 220 nM, respectively. CYP4A11/CYP4F2-IN-2 inhibits 20-HETE production in rat kidney and has potential inhibitory effects on diabetic nephropathy and autosomal dominant polycystic kidney disease[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Metabolic Disease
Target	CYP4A11, CYP4F2[1]
References	[1]. Kawamura M et al. Introduction of a carboxylic acid group into pyrazolylpyridine derivatives increased selectivity for inhibition of the 20-HETE synthase CYP4A11/4F2[J]. Bioorganic & Medicinal Chemistry, 2023: 117505.

Molecular Formula	C₁₉H₂₇N₃O₄
Molecular Weight	361.44