2280834-99-1

2280834-99-1 structure
2280834-99-1 structure
  • Name: CYP4A11/CYP4F2-IN-2
  • Chemical Name: CYP4A11/CYP4F2-IN-2
  • CAS Number: 2280834-99-1
  • Molecular Formula: C19H27N3O4
  • Molecular Weight: 361.44
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
  • Create Date: 2024-02-20 21:24:13
  • Modify Date: 2024-02-20 21:24:13
  • CYP4A11/CYP4F2-IN-2 (compound 15) is an orally available inhibitor of CYP4A11/4F2 with IC50s of 120 nM and 220 nM, respectively. CYP4A11/CYP4F2-IN-2 inhibits 20-HETE production in rat kidney and has potential inhibitory effects on diabetic nephropathy and autosomal dominant polycystic kidney disease[1].

Name CYP4A11/CYP4F2-IN-2
Description CYP4A11/CYP4F2-IN-2 (compound 15) is an orally available inhibitor of CYP4A11/4F2 with IC50s of 120 nM and 220 nM, respectively. CYP4A11/CYP4F2-IN-2 inhibits 20-HETE production in rat kidney and has potential inhibitory effects on diabetic nephropathy and autosomal dominant polycystic kidney disease[1].
Related Catalog
Target

CYP4A11, CYP4F2[1]

References

[1]. Kawamura M et al. Introduction of a carboxylic acid group into pyrazolylpyridine derivatives increased selectivity for inhibition of the 20-HETE synthase CYP4A11/4F2[J]. Bioorganic & Medicinal Chemistry, 2023: 117505.

Molecular Formula C19H27N3O4
Molecular Weight 361.44
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