HDACs/mTOR Inhibitor 1

Modify Date: 2024-01-12 17:57:20

HDACs/mTOR Inhibitor 1 structure	Common Name	HDACs/mTOR Inhibitor 1
	CAS Number	2271413-06-8	Molecular Weight	566.65
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₈H₃₈N₈O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HDACs/mTOR Inhibitor 1

HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo[1].

Name	HDACs/mTOR Inhibitor 1

Description	HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo[1].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC1:0.19 nM (IC50) HDAC6:1.8 nM (IC50) mTOR:1.2 nM (IC50)
References	[1]. Chen Y, et al. Discovery of a Novel Dual Histone Deacetylases (HDACs) and Mammalian Target of Rapamycin (mTOR) Target Inhibitor as a Promising Strategy for Cancer Therapy. J Med Chem. 2019 Jan 10.

Molecular Formula	C₂₈H₃₈N₈O₅
Molecular Weight	566.65

Hazard Codes	Xi

HDACs/mTOR Inhibitor 1

Use of HDACs/mTOR Inhibitor 1

Names

HDACs/mTOR Inhibitor 1 Biological Activity

Chemical & Physical Properties

Safety Information