PI3K/mTOR Inhibitor-2

Modify Date: 2024-01-02 18:35:31

PI3K/mTOR Inhibitor-2 structure	Common Name	PI3K/mTOR Inhibitor-2
	CAS Number	1848242-58-9	Molecular Weight	478.86
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₃ClF₂N₄O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PI3K/mTOR Inhibitor-2

PI3K/mTOR Inhibitor-2 is a potent dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/34/16/1 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ and 4.7 nM for mTOR[1]. Antitumor activity[1].

Name	PI3K/mTOR Inhibitor-2

Description	PI3K/mTOR Inhibitor-2 is a potent dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/34/16/1 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ and 4.7 nM for mTOR[1]. Antitumor activity[1].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Target	PI3Kα:3.4 nM (IC50) PI3Kβ:34 nM (IC50) PI3Kδ:16 nM (IC50) PI3Kγ:1 nM (IC50) mTOR:4.7 nM (IC50)
In Vitro	PI3K/mTOR Inhibitor-2 (Compound 31) inhibits p-AKT and p-p70s6k in MCF-7 cells with IC50s of 11.6 and 89.2 nM, respectively[1].
References	[1]. Yu T, et al. Discovery of Pyridopyrimidinones as Potent and Orally Active Dual Inhibitors of PI3K/mTOR. ACS Med Chem Lett. 2018 Feb 27;9(3):256-261.

Molecular Formula	C₂₀H₁₃ClF₂N₄O₄S
Molecular Weight	478.86

DC Chemicals Limited
China
Product Name: PI3K/mTOR Inhibitor-2
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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