1621718-37-3

1621718-37-3 structure

Name: PI3K/mTOR Inhibitor-13
Chemical Name: PI3K/mTOR Inhibitor-13
CAS Number: 1621718-37-3
Molecular Formula: C₂₀H₁₃F₂N₅O₃S
Molecular Weight: 441.41
Catalog: Signaling Pathways PI3K/Akt/mTOR mTOR
Create Date: 2023-05-20 08:57:55
Modify Date: 2025-09-14 18:06:48
PI3K/mTOR Inhibitor-13 is an orally active dual inhibitor of phosphoinositol 3-kinase (PI3K) and mTOR kinase. PI3K/mTOR Inhibitor-13 has potential applications in sexual diseases, solid tumor and idiopathic pulmonary fibrosis (IPF)[1][2].

Name	PI3K/mTOR Inhibitor-13

Description	PI3K/mTOR Inhibitor-13 is an orally active dual inhibitor of phosphoinositol 3-kinase (PI3K) and mTOR kinase. PI3K/mTOR Inhibitor-13 has potential applications in sexual diseases, solid tumor and idiopathic pulmonary fibrosis (IPF)[1][2].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
In Vitro	PI3K/mTOR Inhibitor-13 (Compound A) (0-2 µM；48 h) 以剂量依赖性方式抑制 HFL1 细胞的增值[1]。 Cell Proliferation Assay[1] Cell Line: HFL1 cells. Concentration: 0, 0.03125, 0.0125, 0.025, 0.05, 0.0625, 0.1, 0.125, 0.2, 0.25, 0.4, 0.5, 1 and 2 µM. Incubation Time: 48 h. Result: Showed inhibitory for HFL1 cells. Western Blot Analysis[1] Cell Line: HFL1 cells. Concentration: 200 nM. Incubation Time: 48 h. Result: Increased the expression of α-SMA/Tubulin.
In Vivo	PI3K/mTOR Inhibitor-13 的药代动力学 (PK) 参数[2] Species Administration manner Dose (mg/kg) T1/2 (h) AUClast (ng•h/mL) Cl/F (L/h/kg) Vss (L/kg) F (%) Rat Intravenous injection 2 2.77 7069 0.29 0.85 94.75 Mice Intravenous injection 1 5.45 57059 0.02 0.13 79.3 Dog Intravenous injection 1 0.67 3672 0.27 0.23 108.5 Monkey Intravenous injection 1 9.70 5978 0.16 0.92 59.8
References	[1]. Cao S, et al. Pharmaceutical combination or pharmaceutical composition for treatment of fibrotic diseases. World Intellectual Property Organization. WO2020078445. [2]. Xi N, et al. Aromatic heterocyclic compounds, pharmaceutical composition containing compounds and application of pharmaceutical composition.China.CN103965199.

Molecular Formula	C₂₀H₁₃F₂N₅O₃S
Molecular Weight	441.41

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