2361009-23-4

2361009-23-4 structure

Name: PI3K/mTOR Inhibitor-13 sodium
Chemical Name: PI3K/mTOR Inhibitor-13 sodium
CAS Number: 2361009-23-4
Molecular Formula: C₂₀H₁₃F₂N₅NaO₃S
Molecular Weight: 464.40
Catalog: Signaling Pathways PI3K/Akt/mTOR mTOR
Create Date: 2023-05-20 14:17:06
Modify Date: 2024-04-03 10:01:17
PI3K/mTOR Inhibitor-13 sodium is an orally active dual inhibitor of phosphoinositol 3-kinase (PI3K) and mTOR kinase. PI3K/mTOR Inhibitor-13 sodium has potential applications in sexual diseases, solid tumor and idiopathic pulmonary fibrosis (IPF)[1][2].

Name	PI3K/mTOR Inhibitor-13 sodium

Description	PI3K/mTOR Inhibitor-13 sodium is an orally active dual inhibitor of phosphoinositol 3-kinase (PI3K) and mTOR kinase. PI3K/mTOR Inhibitor-13 sodium has potential applications in sexual diseases, solid tumor and idiopathic pulmonary fibrosis (IPF)[1][2].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
In Vitro	PI3K/mTOR Inhibitor-13 sodium (Compound A) (0-2 µM；48 h) 以剂量依赖性方式抑制 HFL1 细胞的增值[1]。 Cell Proliferation Assay[1] Cell Line: HFL1 cells. Concentration: 0, 0.03125, 0.0125, 0.025, 0.05, 0.0625, 0.1, 0.125, 0.2, 0.25, 0.4, 0.5, 1 and 2 µM. Incubation Time: 48 h. Result: Showed inhibitory for HFL1 cells. Western Blot Analysis[1] Cell Line: HFL1 cells. Concentration: 200 nM. Incubation Time: 48 h. Result: Increased the expression of α-SMA/Tubulin.
In Vivo	PI3K/mTOR Inhibitor-13 sodium 的药代动力学 (PK) 参数[2] Species Administration manner Dose (mg/kg) T1/2 (h) AUClast (ng•h/mL) Cl/F (L/h/kg) Vss (L/kg) F (%) Rat Intravenous injection 2 2.77 7069 0.29 0.85 94.75 Mice Intravenous injection 1 5.45 57059 0.02 0.13 79.3 Dog Intravenous injection 1 0.67 3672 0.27 0.23 108.5 Monkey Intravenous injection 1 9.70 5978 0.16 0.92 59.8
References	[1]. Cao S, et al. Pharmaceutical combination or pharmaceutical composition for treatment of fibrotic diseases. World Intellectual Property Organization. WO2020078445. [2]. Xi N, et al. Aromatic heterocyclic compounds, pharmaceutical composition containing compounds and application of pharmaceutical composition.China.CN103965199.

Molecular Formula	C₂₀H₁₃F₂N₅NaO₃S
Molecular Weight	464.40

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

2361009-23-4	1621718-37-3
2361215-32-7	2456295-60-4
2456295-65-9	2456295-59-1
2492376-85-7	1392421-71-4
1363338-53-7	1949802-49-6
2742019-86-7	2742062-04-8
2742068-15-9	2742078-93-7
2741889-71-2	2742063-92-7
2741922-81-4	2742012-02-6
2742019-90-3	2742059-21-6