Thalidomide-NH-PEG2-C2-NH2 hydrochloride

Modify Date: 2025-08-25 16:45:45

Thalidomide-NH-PEG2-C2-NH2 hydrochloride structure	Common Name	Thalidomide-NH-PEG2-C2-NH2 hydrochloride
	CAS Number	2245697-87-2	Molecular Weight	440.88
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₅ClN₄O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Thalidomide-NH-PEG2-C2-NH2 hydrochloride

Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].

Name	Thalidomide-NH-PEG2-C2-NH2 hydrochloride

Description	Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.

Molecular Formula	C₁₉H₂₅ClN₄O₆
Molecular Weight	440.88

Hazard Codes	Xi

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