2376990-30-4

2376990-30-4 structure

Name: Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride
Chemical Name: Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride
CAS Number: 2376990-30-4
Molecular Formula: C₂₁H₂₇ClN₄O₈
Molecular Weight: 498.91
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2020-06-01 10:24:21
Modify Date: 2024-08-19 11:20:55
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride incorporates an E3 ligase ligand and a linker, can be an immunomodulater for the treatment of cancer[1].

Name	Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride

Description	Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride incorporates an E3 ligase ligand and a linker, can be an immunomodulater for the treatment of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. ARYL SULFONOHYDRAZIDES. WO 2017/176958 A1.