Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride

Modify Date: 2024-08-19 11:20:55

Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride structure	Common Name	Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride
	CAS Number	2376990-30-4	Molecular Weight	498.91
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₇ClN₄O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride

Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride incorporates an E3 ligase ligand and a linker, can be an immunomodulater for the treatment of cancer[1].

Name	Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride

Description	Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride incorporates an E3 ligase ligand and a linker, can be an immunomodulater for the treatment of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. ARYL SULFONOHYDRAZIDES. WO 2017/176958 A1.

Molecular Formula	C₂₁H₂₇ClN₄O₈
Molecular Weight	498.91
Storage condition	-20°C