2376990-31-5

2376990-31-5 structure

Name: Thalidomide-O-amido-C6-NH2 hydrochloride
Chemical Name: Thalidomide-O-amido-C6-NH2 hydrochloride
CAS Number: 2376990-31-5
Molecular Formula: C₂₁H₂₇ClN₄O₆
Molecular Weight: 466.92
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2020-06-01 18:36:23
Modify Date: 2024-07-23 20:29:34
Thalidomide-O-amido-C6-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

Name	Thalidomide-O-amido-C6-NH2 hydrochloride

Description	Thalidomide-O-amido-C6-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Bradner J, et al. Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses. WO 2017024318 A1

Molecular Formula	C₂₁H₂₇ClN₄O₆
Molecular Weight	466.92

Hazard Codes	Xi