2245697-85-0

2245697-85-0 structure

Name: Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride
Chemical Name: Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride
CAS Number: 2245697-85-0
Molecular Formula: C₂₅H₃₅ClN₄O₁₀
Molecular Weight: 587.02
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2020-06-01 20:03:28
Modify Date: 2025-09-20 18:49:26
Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

Name	Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride
Synonyms	MFCD31656718

Description	Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO2016105518A1.

Molecular Formula	C₂₅H₃₅ClN₄O₁₀
Molecular Weight	587.02

Hazard Codes	Xi