Thalidomide-NH-PEG1-C2-NH2
Modify Date: 2025-08-26 15:38:43
Thalidomide-NH-PEG1-C2-NH2 structure
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Common Name | Thalidomide-NH-PEG1-C2-NH2 | ||
|---|---|---|---|---|
| CAS Number | 2138439-12-8 | Molecular Weight | 360.365 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 660.5±55.0 °C at 760 mmHg | |
| Molecular Formula | C17H20N4O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 353.3±31.5 °C | |
Use of Thalidomide-NH-PEG1-C2-NH2Thalidomide-NH-PEG1-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. |
| Name | 4-{[2-(2-Aminoethoxy)ethyl]amino}-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
|---|---|
| Synonym | More Synonyms |
| Description | Thalidomide-NH-PEG1-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. |
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| Related Catalog | |
| Target |
Cereblon |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 660.5±55.0 °C at 760 mmHg |
| Molecular Formula | C17H20N4O5 |
| Molecular Weight | 360.365 |
| Flash Point | 353.3±31.5 °C |
| Exact Mass | 360.143372 |
| LogP | -1.06 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.647 |
| Hazard Codes | Xi |
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| 1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-aminoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)- |
| 4-{[2-(2-Aminoethoxy)ethyl]amino}-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |