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2138439-12-8

2138439-12-8 structure
2138439-12-8 structure
  • Name: Thalidomide-NH-PEG1-C2-NH2
  • Chemical Name: 4-{[2-(2-Aminoethoxy)ethyl]amino}-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
  • CAS Number: 2138439-12-8
  • Molecular Formula: C17H20N4O5
  • Molecular Weight: 360.365
  • Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
  • Create Date: 2021-09-10 06:31:52
  • Modify Date: 2024-01-14 10:26:05
  • Thalidomide-NH-PEG1-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Name 4-{[2-(2-Aminoethoxy)ethyl]amino}-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Synonyms 1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-aminoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
4-{[2-(2-Aminoethoxy)ethyl]amino}-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Description Thalidomide-NH-PEG1-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
Related Catalog
Target

Cereblon

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Density 1.4±0.1 g/cm3
Boiling Point 660.5±55.0 °C at 760 mmHg
Molecular Formula C17H20N4O5
Molecular Weight 360.365
Flash Point 353.3±31.5 °C
Exact Mass 360.143372
LogP -1.06
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.647
Hazard Codes Xi
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