SNIPER(ABL)-033

Modify Date: 2025-08-25 11:08:05

SNIPER(ABL)-033 structure	Common Name	SNIPER(ABL)-033
	CAS Number	2222354-18-7	Molecular Weight	1211.42
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₆₁H₇₃F₃N₁₀O₉S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SNIPER(ABL)-033

SNIPER(ABL)-033, conjugating HG-7-85-01 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 0.3 μM[1].

Name	SNIPER(ABL)-033

Description	SNIPER(ABL)-033, conjugating HG-7-85-01 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 0.3 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl
References	[1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

Molecular Formula	C₆₁H₇₃F₃N₁₀O₉S₂
Molecular Weight	1211.42
InChIKey	NJCPVTOZWPVLBE-XOIMNWENSA-N
SMILES	CCN1CCN(Cc2ccc(NC(=O)c3cccc(-c4ccc5nc(NC(=O)COCCOCCOCCOc6cccc(C(=O)c7csc(C8CCCN8C(=O)C(NC(=O)C(C)NC)C8CCCCC8)n7)c6)sc5n4)c3)cc2C(F)(F)F)CC1

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