SNIPER(BRD)-1

Modify Date: 2025-08-27 10:26:20

SNIPER(BRD)-1 Structure
SNIPER(BRD)-1 structure
 Common Name SNIPER(BRD)-1
CAS Number 2095244-54-3 Molecular Weight 1056.73
Density N/A Boiling Point N/A
Molecular Formula C53H66ClN9O8S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SNIPER(BRD)-1


SNIPER(BRD)-1, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation of BRD4 via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1 , cIAP2 and XIAP with IC50s of 6.8 nM, 17 nM, and 49nM, respectively[1].

 Names

Name SNIPER(BRD)-1

 SNIPER(BRD)-1 Biological Activity

Description SNIPER(BRD)-1, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation of BRD4 via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1 , cIAP2 and XIAP with IC50s of 6.8 nM, 17 nM, and 49nM, respectively[1].
Related Catalog
Target

BRD4

cIAP1:6.8 nM (IC50)

cIAP2:17 nM (IC50)

XIAP:49 nM (Ki)

SNIPER

References

[1]. Ohoka N, et al. Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER). Chem Pharm Bull (Tokyo). 2019 Mar 1;67(3):203-209.

 Chemical & Physical Properties

Molecular Formula C53H66ClN9O8S2
Molecular Weight 1056.73
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