SNIPER(BRD)-1
Modify Date: 2025-08-27 10:26:20
SNIPER(BRD)-1 structure
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Common Name | SNIPER(BRD)-1 | ||
|---|---|---|---|---|
| CAS Number | 2095244-54-3 | Molecular Weight | 1056.73 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C53H66ClN9O8S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SNIPER(BRD)-1SNIPER(BRD)-1, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation of BRD4 via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1 , cIAP2 and XIAP with IC50s of 6.8 nM, 17 nM, and 49nM, respectively[1]. |
| Name | SNIPER(BRD)-1 |
|---|
| Description | SNIPER(BRD)-1, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation of BRD4 via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1 , cIAP2 and XIAP with IC50s of 6.8 nM, 17 nM, and 49nM, respectively[1]. |
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| Related Catalog | |
| Target |
BRD4 cIAP1:6.8 nM (IC50) cIAP2:17 nM (IC50) XIAP:49 nM (Ki) SNIPER |
| References |
| Molecular Formula | C53H66ClN9O8S2 |
|---|---|
| Molecular Weight | 1056.73 |
| InChIKey | FVDSZRCRCFMYQV-CDYWKMCDSA-N |
| SMILES | CNC(C)C(=O)NC(C(=O)N1CCCC1c1nc(C(=O)c2cccc(OCCOCCOCCOCCNC(=O)CC3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)c2)cs1)C1CCCCC1 |