SNIPER(ABL)-058

Modify Date: 2024-01-11 12:05:08

SNIPER(ABL)-058 structure	Common Name	SNIPER(ABL)-058
	CAS Number	2222354-61-0	Molecular Weight	1150.39
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₆₂H₇₅N₁₁O₉S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SNIPER(ABL)-058

SNIPER(ABL)-058, conjugating Imatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 μM[1].

Name	SNIPER(ABL)-058

Description	SNIPER(ABL)-058, conjugating Imatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl
References	[1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

Molecular Formula	C₆₂H₇₅N₁₁O₉S
Molecular Weight	1150.39