SNIPER(ABL)-039
Modify Date: 2025-08-24 14:37:19
SNIPER(ABL)-039 structure
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Common Name | SNIPER(ABL)-039 | ||
|---|---|---|---|---|
| CAS Number | 2222354-29-0 | Molecular Weight | 1114.77 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C54H68ClN11O9S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SNIPER(ABL)-039SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively[1]. |
| Name | SNIPER(ABL)-039 |
|---|
| Description | SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively[1]. |
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| Related Catalog | |
| Target |
Abl:0.54 nM (IC50) cIAP1:10 nM (IC50) cIAP2:12 nM (IC50) XIAP:50 nM (IC50) SNIPER Abl:10 nM (DC50) |
| References |
| Molecular Formula | C54H68ClN11O9S2 |
|---|---|
| Molecular Weight | 1114.77 |