SNIPER(AR)-51

Modify Date: 2024-01-14 16:39:27

SNIPER(AR)-51 structure	Common Name	SNIPER(AR)-51
	CAS Number	2113688-43-8	Molecular Weight	984.21
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅₅H₆₅N₇O₈S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SNIPER(AR)-51

SNIPER(AR)-51 (AR-51), consists of a cIAP1 ligand and an androgen ligand, connected by a linker[1]. SNIPER(AR)-51 induces androgen receptor (AR) protein degradation[1].

Name	SNIPER(AR)-51

Description	SNIPER(AR)-51 (AR-51), consists of a cIAP1 ligand and an androgen ligand, connected by a linker[1]. SNIPER(AR)-51 induces androgen receptor (AR) protein degradation[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Androgen Receptor
In Vitro	SNIPER(AR)-51 (3 μM; 24 hours) exhibits a pronounced effect on the cell morphology of VCaP cells to induce apoptosis[1]. SNIPER(AR)-51 (3 μM; 24 hours) induces caspase-3 activation and PARP cleavage in prostate cancer VCaP cells[1]. Apoptosis Analysis[1] Cell Line: Prostate cancer VCaP cells Concentration: 3 μM Incubation Time: 24 hours Result: Induced apoptosis. Western Blot Analysis[1] Cell Line: VCaP cells Concentration: 1 μM and 3 μM Incubation Time: 24 hours Result: Induced caspase-3 activation and PARP cleavage at 3 μM.
References	[1]. Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of AndrogenReceptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575.

Molecular Formula	C₅₅H₆₅N₇O₈S
Molecular Weight	984.21

DC Chemicals Limited
China
Product Name: SNIPER(AR)-51
Price: $Inquiry/25mg $Inquiry/100mg $Inquiry/250mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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