SNIPER(ABL)-024

Modify Date: 2025-08-26 19:16:19

SNIPER(ABL)-024 structure	Common Name	SNIPER(ABL)-024
	CAS Number	2222355-77-1	Molecular Weight	1031.15
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅₂H₆₁F₃N₈O₉S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SNIPER(ABL)-024

SNIPER(ABL)-024, conjugating GNF5 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 5μM[1].

Name	SNIPER(ABL)-024

Description	SNIPER(ABL)-024, conjugating GNF5 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 5μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl
References	[1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

Molecular Formula	C₅₂H₆₁F₃N₈O₉S
Molecular Weight	1031.15
InChIKey	WDQUTOHXUGVTJQ-WUSNILEASA-N
SMILES	CNC(C)C(=O)NC(C(=O)N1CCCC1c1nc(C(=O)c2cccc(OCCOCCOCCOCCNC(=O)c3cccc(-c4cc(Nc5ccc(OC(F)(F)F)cc5)ncn4)c3)c2)cs1)C1CCCCC1

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