POLA1 inhibitor 1

Modify Date: 2024-07-21 12:02:52

POLA1 inhibitor 1 Structure
POLA1 inhibitor 1 structure
Common Name POLA1 inhibitor 1
CAS Number 2217671-41-3 Molecular Weight 417.50
Density N/A Boiling Point N/A
Molecular Formula C26H27NO4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of POLA1 inhibitor 1


POLA1 inhibitor 1 (Compound 12) is an orally active POLA1 inhibitor. POLA1 inhibitor 1 shows antitumor activity against several tumor histotypes and Adarotene-resistant cell line[1].

 Names

Name POLA1 inhibitor 1

 POLA1 inhibitor 1 Biological Activity

Description POLA1 inhibitor 1 (Compound 12) is an orally active POLA1 inhibitor. POLA1 inhibitor 1 shows antitumor activity against several tumor histotypes and Adarotene-resistant cell line[1].
Related Catalog
Target

POLA1[1]

In Vivo POLA1 inhibitor 1 (Compound 12) (15 mg/kg and 50 mg/kg) displays a significantly antitumor effect in HT-29 and MM487 xenografts[1].
References

[1]. Cincinelli R, et al. Novel adamantyl retinoid-related molecules with POLA1 inhibitory activity. Bioorg Chem. 2020 Nov;104:104253.

 Chemical & Physical Properties

Molecular Formula C26H27NO4
Molecular Weight 417.50
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