Shanghai Nianxing Industrial Co., Ltd
China
Product Name: POLA1 inhibitor 1
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2217671-41-3

2217671-41-3 structure

2217671-41-3 structure

Name: POLA1 inhibitor 1
Chemical Name: POLA1 inhibitor 1
CAS Number: 2217671-41-3
Molecular Formula: C₂₆H₂₇NO₄
Molecular Weight: 417.50
Catalog: Research Areas Cancer
Create Date: 2022-08-23 18:14:04
Modify Date: 2024-07-21 12:02:52
POLA1 inhibitor 1 (Compound 12) is an orally active POLA1 inhibitor. POLA1 inhibitor 1 shows antitumor activity against several tumor histotypes and Adarotene-resistant cell line[1].

Name	POLA1 inhibitor 1

Description	POLA1 inhibitor 1 (Compound 12) is an orally active POLA1 inhibitor. POLA1 inhibitor 1 shows antitumor activity against several tumor histotypes and Adarotene-resistant cell line[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	POLA1[1]
In Vivo	POLA1 inhibitor 1 (Compound 12) (15 mg/kg and 50 mg/kg) displays a significantly antitumor effect in HT-29 and MM487 xenografts[1].
References	[1]. Cincinelli R, et al. Novel adamantyl retinoid-related molecules with POLA1 inhibitory activity. Bioorg Chem. 2020 Nov;104:104253.

Molecular Formula	C₂₆H₂₇NO₄
Molecular Weight	417.50

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