POLA1 inhibitor 1

Names

[ Name ]:
POLA1 inhibitor 1

Biological Activity

[Description]:

POLA1 inhibitor 1 (Compound 12) is an orally active POLA1 inhibitor. POLA1 inhibitor 1 shows antitumor activity against several tumor histotypes and Adarotene-resistant cell line[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

POLA1[1]

[In Vivo]

POLA1 inhibitor 1 (Compound 12) (15 mg/kg and 50 mg/kg) displays a significantly antitumor effect in HT-29 and MM487 xenografts[1].

[References]

[1]. Cincinelli R, et al. Novel adamantyl retinoid-related molecules with POLA1 inhibitory activity. Bioorg Chem. 2020 Nov;104:104253.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₇NO₄

[ Molecular Weight ]:
417.50

Related Compounds

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