Tyk2-IN-8

Modify Date: 2024-01-09 20:15:07

Tyk2-IN-8 structure	Common Name	Tyk2-IN-8
	CAS Number	2127109-84-4	Molecular Weight	383.41
	Density	1.46±0.1 g/cm3(Predicted)	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₇N₉	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Tyk2-IN-8

Tyk2-IN-8 (compound 10) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain with an IC50 of 17 nM, used in the treatment of psoriasis[1].

Name	Tyk2-IN-8
Synonym	More Synonyms

Description	Tyk2-IN-8 (compound 10) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain with an IC50 of 17 nM, used in the treatment of psoriasis[1].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
Target	IC50: 17 nM (TYK2 JH1)[1]
In Vitro	Tyk2-IN-8 also inhibits JAK1 (IC50=74 nM) and JAK2 (IC50=383 nM)[1].
References	[1]. Wrobleski ST, et al. Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. J Med Chem. 2019 Jul 18.

Density	1.46±0.1 g/cm3(Predicted)
Molecular Formula	C₂₀H₁₇N₉
Molecular Weight	383.41

MFCD32197240

DC Chemicals Limited
China
Product Name: PF-06826647
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Tyk2-IN-8

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