Tyk2-IN-5

Modify Date: 2024-01-10 14:15:57

Tyk2-IN-5 structure	Common Name	Tyk2-IN-5
	CAS Number	1797432-62-2	Molecular Weight	434.43
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₁₉FN₈O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Tyk2-IN-5

Tyk2-IN-5 (compound 6) is a highly potent, selective and orally active Tyk2 inhibitor and targets the JH2 domain, with a Ki of 0.086 nM for Tyk2 JH2 and an IC50 of 25 nM for IFNα. Highly effective in inhibiting IFNγ production in a rat pharmacodynamics model and fully efficacious in a rat adjuvant arthritis model[1].

Name	Tyk2-IN-5

Description	Tyk2-IN-5 (compound 6) is a highly potent, selective and orally active Tyk2 inhibitor and targets the JH2 domain, with a Ki of 0.086 nM for Tyk2 JH2 and an IC50 of 25 nM for IFNα. Highly effective in inhibiting IFNγ production in a rat pharmacodynamics model and fully efficacious in a rat adjuvant arthritis model[1].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
Target	Tyk2 JH2:0.086 nM (Ki) IFNα:25 nM (IC50)
References	[1]. Liu C, et al. Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors. ACS Med Chem Lett. 2019 Feb 21;10(3):383-388.

Molecular Formula	C₂₁H₁₉FN₈O₂
Molecular Weight	434.43

Tyk2-IN-5

Use of Tyk2-IN-5

Names

Tyk2-IN-5 Biological Activity

Chemical & Physical Properties