1797432-62-2

1797432-62-2 structure

Name: Tyk2-IN-5
Chemical Name: Tyk2-IN-5
CAS Number: 1797432-62-2
Molecular Formula: C₂₁H₁₉FN₈O₂
Molecular Weight: 434.43
Catalog: Signaling Pathways Epigenetics JAK
Create Date: 2019-06-01 11:56:17
Modify Date: 2024-01-10 14:15:57
Tyk2-IN-5 (compound 6) is a highly potent, selective and orally active Tyk2 inhibitor and targets the JH2 domain, with a Ki of 0.086 nM for Tyk2 JH2 and an IC50 of 25 nM for IFNα. Highly effective in inhibiting IFNγ production in a rat pharmacodynamics model and fully efficacious in a rat adjuvant arthritis model[1].

Name	Tyk2-IN-5

Description	Tyk2-IN-5 (compound 6) is a highly potent, selective and orally active Tyk2 inhibitor and targets the JH2 domain, with a Ki of 0.086 nM for Tyk2 JH2 and an IC50 of 25 nM for IFNα. Highly effective in inhibiting IFNγ production in a rat pharmacodynamics model and fully efficacious in a rat adjuvant arthritis model[1].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
Target	Tyk2 JH2:0.086 nM (Ki) IFNα:25 nM (IC50)
References	[1]. Liu C, et al. Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors. ACS Med Chem Lett. 2019 Feb 21;10(3):383-388.

Molecular Formula	C₂₁H₁₉FN₈O₂
Molecular Weight	434.43