Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Deucravacitinib(BMS986165)
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Deucravacitinib(BMS986165)
Price: $2200.0/1g $600.0/100mg $1100.0/250mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Deucravacitinib(BMS986165)
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

Shanghai Amole Biotechnology Co., Ltd.
China
Product Name: Tyk2-IN-4(BMS986165)
Price: ￥Inquiry/10g ￥Inquiry/1g ￥Inquiry/250mg ￥Inquiry/25g
Purity: 99.0%
Stocking Period: Inquiry
Contact: Xiyao Wang
Email: 406104890@qq.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: BMS-986165
Price: ￥Inquiry/25kg
Purity: 99.0%
Stocking Period: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

1609392-27-9

1609392-27-9 structure

1609392-27-9 structure

Name: Tyk2-IN-4(BMS986165)
Chemical Name: Tyk2-IN-4
CAS Number: 1609392-27-9
Molecular Formula: C₂₀H₁₉D₃N₈O₃
Molecular Weight: 425.46
Catalog: Signaling Pathways Epigenetics JAK
Create Date: 2019-01-20 02:32:41
Modify Date: 2025-08-21 17:23:54
Tyk2-IN-4 is a selective, potent, allosteric inhibitor of tyrosine kinase 2 (Tyk2).

Name	Tyk2-IN-4

Description	Tyk2-IN-4 is a selective, potent, allosteric inhibitor of tyrosine kinase 2 (Tyk2).
Related Catalog	Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
Target	Tyk2
In Vitro	Tyk2-IN-4 blocks receptor-mediated Tyk2 activation by stabilizing the regulatory pseudokinase domain of the protein[1].
In Vivo	Lupus-like disease is strongly inhibited in NZB/W mice treated with Tyk2-IN-4. Tyk2-IN-4 is safe and overall well-tolerated. There are no serious adverse events and the frequency of non-serious adverse events are similar in the active (75%) and placebo (76%) groups. After oral administration, Tyk2-IN-4 is rapidly absorbed and exhibits an apparent elimination half-life of 8-15 hours[1].
References	[1]. I Catlett, et al. SAT0226 A first-in-human, study of BMS-986165, a selective, potent, allosteric small molecule inhibitor of tyrosine kinase 2.

Molecular Formula	C₂₀H₁₉D₃N₈O₃
Molecular Weight	425.46

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