2127109-84-4

2127109-84-4 structure

Name: Tyk2-IN-8
Chemical Name: Tyk2-IN-8
CAS Number: 2127109-84-4
Molecular Formula: C₂₀H₁₇N₉
Molecular Weight: 383.41
Catalog: Signaling Pathways Epigenetics JAK
Create Date: 2019-09-08 21:07:51
Modify Date: 2024-01-09 20:15:07
Tyk2-IN-8 (compound 10) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain with an IC50 of 17 nM, used in the treatment of psoriasis[1].

Name	Tyk2-IN-8
Synonyms	MFCD32197240

Description	Tyk2-IN-8 (compound 10) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain with an IC50 of 17 nM, used in the treatment of psoriasis[1].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
Target	IC50: 17 nM (TYK2 JH1)[1]
In Vitro	Tyk2-IN-8 also inhibits JAK1 (IC50=74 nM) and JAK2 (IC50=383 nM)[1].
References	[1]. Wrobleski ST, et al. Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. J Med Chem. 2019 Jul 18.