Tyk2-IN-8

Names

[ Name ]:
Tyk2-IN-8

[Synonym ]:
MFCD32197240

Biological Activity

[Description]:

Tyk2-IN-8 (compound 10) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain with an IC50 of 17 nM, used in the treatment of psoriasis[1].

[Related Catalog]:

Signaling Pathways >> JAK/STAT Signaling >> JAK

Signaling Pathways >> Epigenetics >> JAK

Signaling Pathways >> Stem Cell/Wnt >> JAK

Research Areas >> Inflammation/Immunology

[Target]

IC50: 17 nM (TYK2 JH1)[1]

[In Vitro]

Tyk2-IN-8 also inhibits JAK1 (IC50=74 nM) and JAK2 (IC50=383 nM)[1].

[References]

[1]. Wrobleski ST, et al. Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. J Med Chem. 2019 Jul 18.

Chemical & Physical Properties

[ Density]:
1.46±0.1 g/cm3(Predicted)

[ Molecular Formula ]:
C₂₀H₁₇N₉

[ Molecular Weight ]:
383.41

Tyk2-IN-8

Names

Biological Activity

Chemical & Physical Properties

Related Compounds