Tyk2-IN-9

Names

[ CAS No. ]:
2127109-85-5

[ Name ]:
Tyk2-IN-9

Biological Activity

[Description]:

Tyk2-IN-9 is a potent,selective and specific inhibitor of JAK kinases, inhibits Tyk2, JAK1 and JAK2 with IC50 values of 6 nM, 21nM and 6nM, respectively. Tyk2-IN-9, example 19, is extracted from patent US2017240552A1[1].

[Related Catalog]:

Signaling Pathways >> JAK/STAT Signaling >> JAK
Signaling Pathways >> Epigenetics >> JAK
Signaling Pathways >> Stem Cell/Wnt >> JAK
Research Areas >> Inflammation/Immunology

[Target]

Tyk2:6 nM (IC50)

JAK1:21 nM (IC50)

JAK2:8 nM (IC50)


[In Vitro]

Tyk2-IN-9 has the ability to inhibit IL-12 signaling in a human whole blood with an IC50 value of 28 nM in a flow cytometry assay[1].

[References]

[1]. Matthew Frank Brown, et al. Pyrazolo[1,5-a]pyrazin-4-yl derivatives. Patent US20170240552A1

Chemical & Physical Properties

[ Molecular Formula ]:
C20H17N9

[ Molecular Weight ]:
383.41

Related Compounds