Tyk2-IN-3
Modify Date: 2025-08-27 18:49:41
Tyk2-IN-3 structure
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Common Name | Tyk2-IN-3 | ||
|---|---|---|---|---|
| CAS Number | 1779493-12-7 | Molecular Weight | 520.63 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H24N6O3S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Tyk2-IN-3Tyk2-IN-3 is a Tyk2 pseudokinase inhibitor, with an IC50 of 485 nM. |
| Name | Tyk2-IN-3 |
|---|
| Description | Tyk2-IN-3 is a Tyk2 pseudokinase inhibitor, with an IC50 of 485 nM. |
|---|---|
| Related Catalog | |
| Target |
Tyk2:485 nM (IC50) |
| In Vivo | Tyk2-IN-3 (compound 1) is very potent against the Tyk2 pseudokinase (99% inhibition at 1 μM) but lacks potency against all other kinases in the kinome assay panel except IKK (96% inhibition) and the JAK1 pseudokinase domain (99% inhibition at 1 μM). No evidence of binding to the catalytic domain of Tyk2 or any other JAK family kinase is evident at 1 μM, and subsequent enzymatic assays confirm the lack of activity against purified catalytic domains (IC50>>2 μM). The pseudokinase domains of JAK2 and JAK3 are not part of the kinome screening panel. In the IL-23-stimulated kit225 T cell assay, Tyk2-IN-3 inhibits the stimulated response with an IC50 of 485±143 nM (n=3)[1]. |
| References |
| Molecular Formula | C25H24N6O3S2 |
|---|---|
| Molecular Weight | 520.63 |
| InChIKey | SRRNUFQCQFVAPF-CQSZACIVSA-N |
| SMILES | CNc1nc2sc(-c3cccc(C(C)NC(=O)c4ccccc4S(C)(=O)=O)c3)nc2c2c1ncn2C |